It was first described in 1904 by junius but was defined as we now recognize it in the 1970s. Serpiginous choroiditis sc is defined as a rare type of posterior uveitis or choroiditis. Objective to investigate optical coherence tomography oct characteristics of tuberculous serpiginouslike choroiditis tbslc and serpiginous choroiditis sc and to perform oct to differentiate between these conditions. Tb choroiditis may involve any or all quadrants of the fundus while sarcoid choroiditis tends to involve its inferior aspect. Serpiginous choroiditis, also called geographic helicoid peripapillary choroidopathy or geographic choroiditis, is a rare, usually bilateral, chronically recurring inflammatory disease of unknown cause that primarily involves the choroid and retinal pigment epithelium rpe. Subsequent destruction of the retina leads to a permanent visual disability, especially when the disease involves the central macula. Fundus autofluorescence in serpiginous choroiditis. These lesions, that may recur, may last from weeks to months and can result in scar tissue. Serpiginous choroiditis sc is a rare, usually bilateral, progressive, recurrent, idiopathic inflammatory disease that primarily affects the inner choroid and retinal pigment epithelium.
The clinical course is marked by progression, regression, and recurrences. Pdf on jan 1, 2002, alejandro rodriguezgarcia and others published serpiginous choroiditis. This has led to a practice pattern of initiating aggressive. Regarding skin ailments in particular, this means that such a disease leaves scar tissue below while continuing to affect the skin above. Common symptoms reported by people with serpiginous choroiditis. Based on clinical presentation, it can be classified into 1 peripapillary, 2 macular, and 3 ampiginous types. Methods retrospective comparative analysis of clinical features of 5 patients with recurrent tbslc and 5 with sc. Optical coherence tomography features of tuberculous. Its etiology is unknown, but it is thought to represent an immunemediated occlusive vasculitis, as suggested by the finding of. Results 14 patients presented with serpiginous like choroiditis over 10 years seven within the last 2 years. Serpiginous choroiditis endstage retina image bank. Uveitis is further classified according to which part of the eye is affected.
I have been taking 1,000 mg of meriva daily, a curcumin compound, for serpiginous choroiditis for 6 months. Objective to compare distinctive clinical features of presumed tuberculous serpiginouslike choroiditis tbslc with classic serpiginous choroiditis sc in patients living in a region that is nonendemic for tuberculosis. Serpiginous choroiditis is a bilateral idiopathic disorder characterized by geographic, helicoid destruction of the choroid and rpe. Enigma of serpiginous choroiditis dutta majumder p, biswas j. In total, 17 patients with the diagnosis of serpiginous choroiditis treated with chlorambucil were identified.
Wang xiao na, you qi sheng, zhao hui ying, peng xiao yan, corresponding author. Serpiginous choroiditis sc is a posterior uveitis displaying a geographic pattern of choroiditis, extending from the juxtapapillary choroid and intermittently spreading centrifugally. Feb 25, 20 imaging device fundus camera description typical serpiginous choroiditis. It is slightly more common in men between 30 and 70 years of age with no predilection for race. More detailed information about the symptoms, causes, and treatments of serpiginous choroiditis is available below symptoms of serpiginous choroiditis. Optical coherence tomography features of tuberculous serpiginous like choroiditis and serpiginous choroiditis. Its etiology is unknown, but it is thought to represent an immunemediated occlusive vasculitis, as suggested by the finding of lymphocytes in the. Serpiginous choroiditis symptoms, diagnosis, treatments. Bilateral full thickness macular holes in association with serpiginous choroiditis. Multifocal choroiditis is a feature of many ocular diseases. Choroiditis, serpiginous nord national organization for.
Serpiginous choroidopathy geographic choroiditis, helicoid peripapillary choroidopathy is a rare disease characterized by progressive destruction of the rpe and choriocapillaris with secondary involvement of the outer retina. Imaging serpiginous choroidopathy with spectral domain. Serpiginous choroiditis sc is an asymmetrically bilateral inflammation of the choroid that leads to loss of choriocapillaris atrophy or loss of. Serpiginous choroiditis an overview sciencedirect topics. Serpiginouslike choroiditis as a marker for tuberculosis. There were 7 women and 8 men with ages ranging from 20. The condition affects the pigmented layer of the retina the retinal pigment epithelium or rpe and the choroid. The cause is unknown, although tuberculosis should be ruled out in all cases. Serpiginous choroiditis is a rare disorder characterized by recurrent lesions affecting two layers of the eye the retinal pigment epithelium and the choriocapillaris. Serpiginous choroiditis is an inflammatory condition of the choroid that affects the outer retina and the rpe. The lesions are noncontiguous to the optic disc and showing centrifugal spread clinical differentiation between autoimmune sc and tubercular msc is mandatory so as to initiate appropriate therapy in time 12. Get a printable copy pdf file of the complete article 2. Serpiginous choroiditis, also known as geographic or helicoid choroidopathy, is an uncommon, chronic, progressive inflammatory condition affecting adult men and women equally in the second to seventh decades of life.
Brief report open access realtime and nested polymerase. A rare chronic disorder characterized by inflammation of small capillaries in the choroids and retina of the eye. Last modified by jennifer hicks on sep 27, 2012 rating 2 ratings appears in miscellaneous conditionkeywords choroiditis, autofluorescence imaging, serpiginous choroiditis, lesion. Algorithm of choroiditis ovi sofia, sudharshan sridharan, jyotirmay biswas abstract choroiditis may present as focal or multifocal lesions, and could be due to infectious or noninfectious etiology. The condition affects the pigmented layer of the retina the retinal pigment. Fundus fluorescein angiography revealed early hypofluorescence of active lesions with gradual increase in fluorescence across the phase of angiogram. Profile of serpiginous choroiditis in a tertiary eye care centre in eastern india kumar saurabh, pradeep kumar panigrahi 1, amitabh kumar, rupak roy 1, jyotirmay biswas purpose. The aim of this paper is to describe a case of serpiginous choroiditis treated with cyclosporine a at a tertiary uveitis referral centre. Serpiginous choroiditis, also known as helicoid or geographic choroidopathy, is a rare, idiopathic inflammatory disease affecting the retinal pigment epithelium, outer retina, and the inner choroid. Pdf enigma of serpiginous choroiditis researchgate. The visual acuity in right eye was counting fingers at 1 meter. Fifteen patients suffering from serpiginous choroiditis were followed up for 1 to 10 years mean 4.
Serpiginouslike choroiditis as a marker for tuberculosis in. Serpiginous choroiditis is a rare inflammatory eye condition that typically develops between age 30 and 70 years. Focal choroidal lesions are commonly caused by toxoplasma infection, tuberculosis, sarcoidosis or serpiginous choroiditis. Serpiginous choroiditis symptoms, diagnosis, treatments and. Serpiginous choroiditis sc is a descriptive term for an intraocular inflammatory disease characterized by a geographic pattern of choroiditis that typically extends from the peripapillary area and affects the overlying retinal pigment epithelium rpe and the outer retina. We investigated the autofluorescence characteristics of two cases of serpiginous choroiditis sc during recurrent acute episodes, and followed them until their resolution. Four had no signs of earlier choroidal inflammation, and in five old choroidal scars. Serpiginous choroiditis and infectious multifocal serpiginoid. Fundus autofluorescence is already used to evaluate inflammatory disorders affecting the chorioretinal interface. Imaging device fundus camera description typical serpiginous choroiditis. Serpiginous choroiditis sc is a posterior uveitis displaying a geographic pattern of choroiditis, extending from the juxtapapillary choroid and intermittently.
May 04, 2020 serpiginous choroidopathy is a rare chronic disease in which inflammation occurs in the sensitive sightenabling structures at the back of the eye. We compared the autofluorescence findings with those obtained with other. Genetic alliance i have been taking 1,000 mg of meriva daily, a curcumin compound, for serpiginous choroiditis for 6 months. This report deals with ninepatients suffering from serpiginous choroiditis. Fundoscopy showed a classic peripapillary serpiginous lesion and a solitary macular lesion. Realtime and nested polymerase chain reaction in the. Serpiginous choroiditis sc is an asymmetrically bilateral inflammation of the choroid that leads to loss of choriocapillaris atrophy or loss of overlying retinal pigment epithelium.
The clinical course, regardless of the presentation, is progressive with multiple recurrences. The role of mycobacterium tuberculosis mtb in msc has been studied by conventional polymerase chain reaction pcr. It usually occurs in otherwise healthy individuals. Serpiginous choroiditis sc is a chronic, recurrent inflammation, primarily affecting the choroid and choriocapillaris, with secondary involvement of the retinal pigment epithelium rpe and. The topic serpiginous choroidopathy you are seeking is a synonym, or alternative name, or is closely related to the medical condition serpiginous choroiditis. To describe the management and longterm outcomes of patients with serpiginous choroiditis treated with alkylating agents. Dec 08, 2014 the cause of serpiginous choroiditis is unknown.
Links to pubmed are also available for selected references. Batlle, md retina associates uploaded on sep 16, 2012. Sep 16, 20 serpiginous choroiditis is a rare inflammatory eye condition that typically develops between age 30 and 70 years. Serpiginous choroiditis, also known as geographic or helicoid choroidopathy, is an uncommon chronic progressive inflammatory disease affecting adult men and women equally in the second to seventh decades of life.
The sole presence of multifocal choroiditis is usually suggestive of tb or sarcoidosis. Serpiginous choroiditis rare diseases and genetic disorders. A 68yearold healthy male presented with a few years of decreased vision bilaterally. It is a chronic, recurrent, and progressive disease that typically affects patients 30 to 60 years of age. Treatment of serpiginous choroiditis with chlorambucil.
There was unilateral decrease in central vision, scotoma, and retinal pigment epithelial atrophy. Optical coherence tomography showed hyperreflectivity in outer retinal layers and loss of ellipsoid zone band. Typically bilateral but sometimes asymmetric, it most commonly affects patients in the fourth to sixth decades of life. This is a case of serpiginous choroidopathy with inactive pattern. Regarding skin ailments in particular, this means that such a disease leaves scar tissue below while continuing to affect the skin above serpiginous choroidopathy is an eye condition. Enigma of serpiginous choroiditis article pdf available in indian journal of ophthalmology 673. Choroiditis definition of choroiditis by the free dictionary. More detailed information about the symptoms, causes, and treatments of serpiginous choroiditis is available below. Seven of 14 patients showed evidence of exposure to. It is a form of uveitis, a term used to describe a number of conditions which are characterised by inflammation within the eye. To study the clinical profile of serpiginous choroiditis in eastern india. Serpiginous choroiditis sc is a chronic, recurrent inflammation, primarily affecting the choroid and choriocapillaris, with secondary involvement of the retinal pigment epithelium rpe and retina 1, 2.
Oct 02, 2008 meriva curcumin treatment for serpiginous choroiditis in. Affected individuals have lesions in the eye that last from weeks to months and involve scarring of the eye tissue. The choroiditis involves the overlying retinal pigment epithelium, and the outer retina. Rating 1 rating appears in miscellaneous conditionkeywords serpiginous choroiditis. Cnv in serpiginous choroidopathy is associated with a poor visual prognosis. Zohar habotwilner md, susan lightman phd, frcp, frcophth, in retinal pharmacotherapy, 2010. Seven of these layers contain nerves, and one layer contains pigmentation retinal.
Diagnosis and management of serpiginous choroiditis. Serpiginous choroiditis sc is a rare, bilateral, idiopathic inflammatory disorder that results in geographic destruction of the retinal pigment epithelium rpe, retina, and choriocapillaris. The lesions are noncontiguous to the optic disc and showing centrifugal spread clinical differentiation between autoimmune sc and tubercular msc is mandatory so as to initiate appropriate therapy in time. Serpiginous choroiditis is a rare, usually bilateral, chronic, progressive, recurrent inflammation of the choroid, retinal pigment epithelium, and choriocapillaris of unknown etiology. The other 3 cases showed early hypofluorescence with late staining characteristic of serpiginous choroiditis. Sweptsource oct angiography of serpiginous choroiditis. He noted worsening of his vision od despite prior treatment with oral and topical corticosteroids. Serpiginous, often referring to some chronic medical affliction, signifies it as slowly progressive or creeping, such as ringworm. Serpiginous choroiditis sc is a rare form of bilateral, chronic, or recurrent posterior uveitis that is thought to involve primarily the choriocapillaris, with subsequent involvement of the retinal pigment epithelium rpe and outer retina. Purpose to report a case of atypical serpiginous choroiditis with previously unreported findings on optical coherence tomographic angiography case report a 35yearold otherwise healthy man had a 1week history of vision loss in his right eye. Dec 22, 2018 serpiginous choroiditis sc is defined as a rare type of posterior uveitis or choroiditis. Aop1 profile of serpiginous choroiditis in a tertiary eye care centre in eastern india kumar saurabh, pradeep kumar panigrahi 1, amitabh kumar, rupak roy1, jyotirmay biswas purpose. This is a pdf file of an unedited manuscript that has been accepted.
Serpiginous definition of serpiginous by medical dictionary. Serpiginous choroiditis is a rare inflammatory eye disorder that is characterized by lesions in the eye. Two patients with chronic serpiginous choroiditis were imaged using two prototype sdoct systems 6m axial resolution. Methods this retrospective, casecontrol study examined consecutively enrolled patients with active tbslc or sc. Results 14 patients presented with serpiginouslike choroiditis over 10 years seven within the last 2 years. Aim to describe the increasing incidence of multifocal outer retinal and inner choroidal inflammation as a marker for intraocular tuberculosis in the uk, a nonendemic area. The retina is the lightsensitive internal coat of the eyeball, consisting of eight layers.
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